Bone Abstracts

Rationale and hypothesis: In ~70% of advanced prostate cancer (PCa) patients, incurable bone metastases are a significant cause of morbidity and mortality. It has been shown that in models of PCa, bone metastases are initiated by a minor subset (<1% of total cell population) that are mitotically quiescent and which have undergone epithelial to mesenchymal transition (EMT). Recent studies have shown that various P2 receptors regulate invasiveness/EMT in different types of c...

Introduction: Patients with multiple myeloma (MM) commonly present with devastating bone disease mediated by increased bone resorption and suppressed bone formation. We have previously shown that blocking activity of the Wnt antagonist Dkk-1 promotes osteoblastogenesis and inhibits development of bone lesions in experimental models of MM. In the 5T murine models of MM, tumour cells home to the bone marrow. Injection of 5T2MM cells into C57BLKalwRij mice results in bone disease...